Liver‐on‐a‐Chip: Bioengineered Multicellular Liver Microtissues for Modeling Advanced Hepatic Fibrosis Driven Through Non‐Alcoholic Fatty Liver Disease (Small 14/2021)

In article number 2007425, Junmin Lee, Ali Khademhosseini, and co-workers present a breakthrough for modeling of non-alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular microtissues liver-on-a-chip system. The consisting four major cell types (primary human hepatocytes, stellate cells, Kupffer endothelial cells) recapitulate the pathogenesis hepatic fibrosis driven by NAFLD.